› 4m4z

X-ray diffraction
2.1Å resolution

SH3 and SH2 domains of human Src-like adaptor protein 2 (SLAP2)

Released:
DOI: 10.2210/pdb4m4z/pdb
PDB entry 4m4z coloured by chain, front view.
PDB entry 4m4z coloured by chain, side view.
PDB entry 4m4z coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of Src-like adaptor protein 2 reveals close association of SH3 and SH2 domains through β-sheet formation.
Wybenga-Groot LE, McGlade CJ
Cell Signal 25 2702-8 (2013)
PMID: 24018043

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Src-like-adapter 2 Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H6Q3 (Residues: 29-193; Coverage: 63%)
Gene names: C20orf156, SLA2, SLAP2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 38.46Å b: 42.43Å c: 46.1Å
α: 90° β: 94.63° γ: 90°
R-values:
R R work R free
0.184 0.182 0.225
Expression system: Escherichia coli

Quick links

Citations

3 review citations

RTK SLAP down: the emerging role of Src-like adaptor protein as a key player in receptor tyrosine kinase signaling.
Wybenga-Groot et al. (2015)
2 more