› 4kuc

X-ray diffraction
2.79Å resolution

Crystal structure of ricin-A chain in complex with the antibody 6C2

Released:
DOI: 10.2210/pdb4kuc/pdb
PDB entry 4kuc coloured by chain, front view.
PDB entry 4kuc coloured by chain, side view.
PDB entry 4kuc coloured by chain, top view.
Source organisms:
Entry authors: Zhu Y, Li X, Teng M

Function and Biology Details

Reaction catalysed: 
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-208798 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ricin A chain Chains: A, I
Molecule details ›
Chains: A, I
Length: 267 amino acids
Theoretical weight: 29.94 KDa
Source organism: Ricinus communis
Expression system: Escherichia coli
UniProt:
  • Canonical: P02879 (Residues: 36-302; Coverage: 49%)
Sequence domains: Ribosome inactivating protein
Structure domains:
mAb6c2 fab-Heavy chain Chains: D, E
Molecule details ›
Chains: D, E
Length: 231 amino acids
Theoretical weight: 25.4 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins
mAb6c2 fab-Light chain Chains: F, H
Molecule details ›
Chains: F, H
Length: 237 amino acids
Theoretical weight: 25.26 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: I222
Unit cell:
a: 108.516Å b: 151.803Å c: 208.418Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.238 0.289
Expression systems:
  • Escherichia coli
  • Not provided

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