Function and Biology Details
Reaction catalysed:
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- DNA topoisomerase, type IIA, domain A
- TOPRIM domain
- DNA topoisomerase, type IIA-like domain superfamily
- DNA gyrase B subunit, C-terminal
- DNA topoisomerase, type IIA, conserved site
- DNA topoisomerase, type IIA, subunit B, C-terminal
- DNA topoisomerase, type IIA
- DNA topoisomerase, type IIA, alpha-helical domain superfamily
2 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
Assembly name:
DNA topoisomerase 4 and DNA (preferred)
PDBe Complex ID:
PDB-CPX-117761 (preferred)
Entry contents:
2 distinct polypeptide molecules
4 distinct DNA molecules
4 distinct DNA molecules
Macromolecules (6 distinct):
DNA topoisomerase 4 subunit A
Molecule details ›
Chains: A, B
Length: 496 amino acids
Theoretical weight: 56.46 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
Sequence domains: DNA gyrase/topoisomerase IV, subunit A
Length: 496 amino acids
Theoretical weight: 56.46 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
- Canonical:
P72525 (Residues: 1-488; Coverage: 59%)
Sequence domains: DNA gyrase/topoisomerase IV, subunit A
DNA topoisomerase 4 subunit B
Molecule details ›
Chains: C, D
Length: 268 amino acids
Theoretical weight: 30.42 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
Sequence domains:
Structure domains: Rossmann fold
Length: 268 amino acids
Theoretical weight: 30.42 KDa
Source organism: Streptococcus pneumoniae TIGR4
Expression system: Escherichia coli
UniProt:
- Canonical: Q59961 (Residues: 404-647; Coverage: 38%)
Sequence domains:
Structure domains: Rossmann fold
