› 4k1o

X-ray diffraction
2.6Å resolution

Crystal structure of the alphaN-catenin actin-binding domain

Released:
DOI: 10.2210/pdb4k1o/pdb
PDB entry 4k1o coloured by chain, front view.
PDB entry 4k1o coloured by chain, side view.
PDB entry 4k1o coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions.
Ishiyama N, Tanaka N, Abe K, Yang YJ, Abbas YM, Umitsu M, Nagar B, Bueler SA, Rubinstein JL, Takeichi M, Ikura M
J Biol Chem 288 15913-25 (2013)
PMID: 23589308

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-178877 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 264 amino acids
Theoretical weight: 29.1 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q61301 (Residues: 651-953; Coverage: 27%)
Gene names: Catna2, Ctnna2
Sequence domains: Vinculin family
Structure domains: Alpha-catenin/vinculin-like

Ligands and Environments

1 bound ligand:
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3212
Unit cell:
a: 112.152Å b: 112.152Å c: 56.316Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.198 0.195 0.231
Expression system: Escherichia coli BL21

Quick links

Citations

16 review citations

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling.
Takeichi M. (2014)
15 more

3 mentions without citation

An autoinhibited structure of α-catenin and its implications for vinculin recruitment to adherens junctions.
Ishiyama et al. (2013)
2 more