› 4jwx

X-ray diffraction
1.5Å resolution

GluN2A ligand-binding core in complex with propyl-NHP5G

Released:
DOI: 10.2210/pdb4jwx/pdb
PDB entry 4jwx coloured by chain, front view.
PDB entry 4jwx coloured by chain, side view.
PDB entry 4jwx coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors.
Hansen KB, Tajima N, Risgaard R, Perszyk RE, Jørgensen L, Vance KM, Ogden KK, Clausen RP, Furukawa H, Traynelis SF
Mol Pharmacol 84 114-27 (2013)
PMID: 23625947

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-169490 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, NMDA 2A Chain: A
Molecule details ›
Chain: A
Length: 280 amino acids
Theoretical weight: 31.43 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00959 (Residues: 404-801; Coverage: 19%)
Gene name: Grin2a
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand 1N4 1 x 1N4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P41212
Unit cell:
a: 52.031Å b: 52.031Å c: 198.823Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.195
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Structure, function, and allosteric modulation of NMDA receptors.
Hansen et al. (2018)
8 more

4 mentions without citation

Advancing NMDA Receptor Physiology by Integrating Multiple Approaches.
Zhou et al. (2017)
3 more