Function and Biology Details
Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Thioredoxin domain
- FAD/NAD(P)-binding domain superfamily
- Thioredoxin
- Thioredoxin-like superfamily
- Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
- FAD/NAD-linked reductase, dimerisation domain superfamily
- Pyridine nucleotide-disulphide oxidoreductase, class I, active site
- FAD/NAD(P)-binding domain
3 more domains
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Thioredoxin 1 and Thioredoxin reductase (preferred)
PDBe Complex ID:
PDB-CPX-158192 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thioredoxin reductase
Molecule details ›
Chains: A, B, C, D
Length: 541 amino acids
Theoretical weight: 59.75 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 541 amino acids
Theoretical weight: 59.75 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
- Canonical:
P61076 (Residues: 77-617; Coverage: 88%)
Sequence domains:
- FAD binding domain
- Pyridine nucleotide-disulphide oxidoreductase
- Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Thioredoxin 1
Molecule details ›
Chains: E, F, G, H
Length: 114 amino acids
Theoretical weight: 12.85 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin
Length: 114 amino acids
Theoretical weight: 12.85 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli
UniProt:
- Canonical: Q7KQL8 (Residues: 2-104; Coverage: 99%)
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin
