› 4ikl

X-ray diffraction
1.9Å resolution

Crystal structure of wild-type human transthyretin in complex with sulindac

Released:
DOI: 10.2210/pdb4ikl/pdb
PDB entry 4ikl coloured by chain, front view.
PDB entry 4ikl coloured by chain, side view.
PDB entry 4ikl coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lima LMTR, Polikarpov I

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand SUZ 2 x SUZ
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU ULTRAX 18
Spacegroup: P21212
Unit cell:
a: 43.09Å b: 85.54Å c: 64.11Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.244
Expression system: Escherichia coli

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