Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-128711 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Tyrosine-protein kinase JAK2
Molecule details ›
Chains: A, B, C, D
Length: 297 amino acids
Theoretical weight: 35.11 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Length: 297 amino acids
Theoretical weight: 35.11 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
Q62120 (Residues: 836-1132; Coverage: 26%)
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Interleukin-6 receptor subunit beta
Molecule details ›
Chains: I, J, K, L
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
Length: 15 amino acids
Theoretical weight: 1.61 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
- Canonical: Q00560 (Residues: 750-764; Coverage: 2%)
Suppressor of cytokine signaling 3
Molecule details ›
Chains: E, F, G, H
Length: 143 amino acids
Theoretical weight: 15.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
Sequence domains: SH2 domain
Structure domains: SH2 domain
Length: 143 amino acids
Theoretical weight: 15.64 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
- Canonical: O35718 (Residues: 38-128; Coverage: 40%)
Sequence domains: SH2 domain
Structure domains: SH2 domain
