› 4gew

X-ray diffraction
2.35Å resolution

Crystal structure of TDP2 from C. elegans

Released:
DOI: 10.2210/pdb4gew/pdb
PDB entry 4gew coloured by chain, front view.
PDB entry 4gew coloured by chain, side view.
PDB entry 4gew coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
Shi K, Kurahashi K, Gao R, Tsutakawa SE, Tainer JA, Pommier Y, Aihara H
Nat Struct Mol Biol 19 1372-7 (2012)
PMID: 23104058

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195049 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5'-tyrosyl-DNA phosphodiesterase Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 40.94 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9XWG3 (Residues: 1-362; Coverage: 100%)
Gene name: Y63D3A.4
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GOL 9 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P41212
Unit cell:
a: 101.273Å b: 101.273Å c: 120.891Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.207
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).
Pommier et al. (2014)
10 more

3 mentions without citation

Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
Shi et al. (2012)
2 more