› 4fo0

X-ray diffraction
2.6Å resolution

Human actin-related protein Arp8 in its ATP-bound state

Released:
DOI: 10.2210/pdb4fo0/pdb
PDB entry 4fo0 coloured by chain, front view.
PDB entry 4fo0 coloured by chain, side view.
PDB entry 4fo0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Actin-related protein 8 and its contribution to nucleosome binding.
Gerhold CB, Winkler DD, Lakomek K, Seifert FU, Fenn S, Kessler B, Witte G, Luger K, Hopfner KP
Nucleic Acids Res 40 11036-46 (2012)
PMID: 22977180

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-190692 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin-related protein 8 Chain: A
Molecule details ›
Chain: A
Length: 593 amino acids
Theoretical weight: 67.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H981 (Residues: 34-624; Coverage: 95%)
Gene names: ACTR8, ARP8, INO80N
Sequence domains: Actin
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MG 1 x MG
Ligand ATP 1 x ATP
Ligand GOL 8 x GOL
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2221
Unit cell:
a: 80.875Å b: 151.262Å c: 173.35Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.166 0.163 0.21
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Regulating the chromatin landscape: structural and mechanistic perspectives.
Bartholomew B. (2014)
9 more

5 mentions without citation

Structure of Actin-related protein 8 and its contribution to nucleosome binding.
Gerhold et al. (2012)
4 more