› 4f4l

X-ray diffraction
3.49Å resolution

Open Channel Conformation of a Voltage Gated Sodium Channel

Released:
DOI: 10.2210/pdb4f4l/pdb
PDB entry 4f4l coloured by chain, front view.
PDB entry 4f4l coloured by chain, side view.
PDB entry 4f4l coloured by chain, top view.
Source organism: Magnetococcus marinus MC-1
Primary publication:
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing.
McCusker EC, Bagnéris C, Naylor CE, Cole AR, D'Avanzo N, Nichols CG, Wallace BA
Nat Commun 3 1102 (2012)
PMID: 23033078

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106115 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 112 amino acids
Theoretical weight: 12.44 KDa
Source organism: Magnetococcus marinus MC-1
Expression system: Escherichia coli
UniProt:
  • Canonical: A0L5S6 (Residues: 130-237; Coverage: 39%)
Gene name: Mmc1_0798
Sequence domains: Ion transport protein
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 117.07Å b: 74.08Å c: 107.93Å
α: 90° β: 118.26° γ: 90°
R-values:
R R work R free
0.271 0.271 0.285
Expression system: Escherichia coli

Quick links

Citations

41 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
40 more

22 mentions without citation

Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.
Payandeh et al. (2015)
21 more