› 4f3j

X-ray diffraction
1.34Å resolution

Crystal Structure of Trimeric gC1q Domain of Human C1QTNF5 associated with Late-onset Retinal Macular Degeneration

Released:
DOI: 10.2210/pdb4f3j/pdb
PDB entry 4f3j coloured by chain, front view.
PDB entry 4f3j coloured by chain, side view.
PDB entry 4f3j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration.
Tu X, Palczewski K
J Struct Biol 180 439-46 (2012)
PMID: 22892318

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189789 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Complement C1q tumor necrosis factor-related protein 5 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BXJ0 (Residues: 103-243; Coverage: 62%)
Gene names: C1QTNF5, CTRP5, UNQ303/PRO344
Sequence domains: C1q domain
Structure domains: Jelly Rolls

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: R3
Unit cell:
a: 46.621Å b: 46.621Å c: 138.83Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.138 0.136 0.165
Expression system: Escherichia coli

Quick links

Citations

6 review citations

Metabolic function of the CTRP family of hormones.
Seldin et al. (2014)
5 more

10 mentions without citation

Structural commonality of C1q TNF-related proteins and their potential to activate relaxin/insulin-like family peptide receptor 1 signalling pathways in cancer cells.
Klonisch et al. (2017)
9 more