› 4f0e

X-ray diffraction
2.4Å resolution

Human ADP-RIBOSYLTRANSFERASE 7 (ARTD7/PARP15), CATALYTIC DOMAIN IN COMPLEX WITH STO1102

Released:
DOI: 10.2210/pdb4f0e/pdb
PDB entry 4f0e coloured by chain, front view.
PDB entry 4f0e coloured by chain, side view.
PDB entry 4f0e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of ligands for ADP-ribosyltransferases via docking-based virtual screening.
Andersson CD, Karlberg T, Ekblad T, Lindgren AE, Thorsell AG, Spjut S, Uciechowska U, Niemiec MS, Wittung-Stafshede P, Weigelt J, Elofsson M, Schüler H, Linusson A
J Med Chem 55 7706-18 (2012)
PMID: 22823910

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-175095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein mono-ADP-ribosyltransferase PARP15 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 200 amino acids
Theoretical weight: 22.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q460N3 (Residues: 481-678; Coverage: 29%)
Gene names: BAL3, PARP15
Sequence domains: Poly(ADP-ribose) polymerase catalytic domain
Structure domains: Phosphoenolpyruvate Carboxykinase; domain 3

Ligands and Environments

1 bound ligand:
Ligand 0RU 3 x 0RU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 69.676Å b: 45.383Å c: 123.389Å
α: 90° β: 90.25° γ: 90°
R-values:
R R work R free
0.224 0.22 0.287
Expression system: Escherichia coli

Quick links

Citations

9 review citations

PARP-1 mechanism for coupling DNA damage detection to poly(ADP-ribose) synthesis.
Langelier et al. (2013)
8 more

3 mentions without citation

Structural basis for lack of ADP-ribosyltransferase activity in poly(ADP-ribose) polymerase-13/zinc finger antiviral protein.
Karlberg et al. (2015)
2 more