› 4erw

X-ray diffraction
2Å resolution

CDK2 in complex with staurosporine

Released:
DOI: 10.2210/pdb4erw/pdb
PDB entry 4erw coloured by chain, front view.
PDB entry 4erw coloured by chain, side view.
PDB entry 4erw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel approach to the discovery of small-molecule ligands of CDK2.
Martin MP, Alam R, Betzi S, Ingles DJ, Zhu JY, Schönbrunn E
Chembiochem 13 2128-36 (2012)
PMID: 22893598

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand STU 1 x STU
Ligand EDO 16 x EDO
1 modified residue:
Ligand OCS 1 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 53.63Å b: 71.34Å c: 72.36Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.196 0.244
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Cyclin dependent kinase (CDK) inhibitors as anticancer drugs.
Sánchez-Martínez et al. (2015)
6 more

5 mentions without citation

A novel approach to the discovery of small-molecule ligands of CDK2.
Martin et al. (2012)
4 more