4e4d

X-ray diffraction
2.7Å resolution

Crystal structure of mouse RANKL-OPG complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero pentamer (preferred)
hetero hexamer
PDBe Complex ID:
PDB-CPX-126656 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tumor necrosis factor ligand superfamily member 11, soluble form Chain: X
Molecule details ›
Chain: X
Length: 155 amino acids
Theoretical weight: 17.38 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O35235 (Residues: 162-316; Coverage: 49%)
Gene names: Opgl, Rankl, Tnfsf11, Trance
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls
Tumor necrosis factor receptor superfamily member 11B Chain: R
Molecule details ›
Chain: R
Length: 183 amino acids
Theoretical weight: 20.37 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O08712 (Residues: 22-197; Coverage: 46%)
Gene names: Ocif, Opg, Tnfrsf11b
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P63
Unit cell:
a: 109.763Å b: 109.763Å c: 78.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.194 0.23
Expression systems:
  • Escherichia coli BL21(DE3)
  • Spodoptera frugiperda