› 4e0l

X-ray diffraction
1.7Å resolution

FYLLYYT segment from human Beta 2 Microglobulin (62-68) displayed on 54-membered macrocycle scaffold

Released:
DOI: 10.2210/pdb4e0l/pdb
PDB entry 4e0l coloured by chain, front view.
PDB entry 4e0l coloured by chain, side view.
PDB entry 4e0l coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu C, Zhao M, Jiang L, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D
Proc Natl Acad Sci U S A 109 20913-8 (2012)
PMID: 23213214

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158376 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-2-microglobulin form pI 5.3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 14 amino acids
Theoretical weight: 1.85 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P61769 (Residues: 81-88; Coverage: 8%)
Gene names: B2M, CDABP0092, HDCMA22P

Ligands and Environments

1 bound ligand:
Ligand MPD 2 x MPD
1 modified residue:
Ligand ORN 8 x ORN

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: C2
Unit cell:
a: 66.99Å b: 40.78Å c: 23.99Å
α: 90° β: 98.76° γ: 90°
R-values:
R R work R free
0.231 0.228 0.258
Expression system: Not provided

Quick links

Citations

26 review citations

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases.
Jucker et al. (2013)
25 more

1 mention without citation

Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates.
Liu et al. (2012)