› 4dov

X-ray diffraction
1.7Å resolution

Structure of free mouse ORC1 BAH domain

Released:
DOI: 10.2210/pdb4dov/pdb
PDB entry 4dov coloured by chain, front view.
PDB entry 4dov coloured by chain, side view.
PDB entry 4dov coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.
Kuo AJ, Song J, Cheung P, Ishibe-Murakami S, Yamazoe S, Chen JK, Patel DJ, Gozani O
Nature 484 115-9 (2012)
PMID: 22398447

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Origin recognition complex subunit 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 163 amino acids
Theoretical weight: 19.04 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Z1N2 (Residues: 9-170; Coverage: 19%)
Gene names: Orc1, Orc1l
Sequence domains: BAH domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 4 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P21
Unit cell:
a: 49.922Å b: 53.916Å c: 71.971Å
α: 90° β: 102.41° γ: 90°
R-values:
R R work R free
0.216 0.215 0.243
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

85 review citations

Perceiving the epigenetic landscape through histone readers.
Musselman et al. (2012)
84 more

4 mentions without citation

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.
Kuo et al. (2012)
3 more