› 4cyi

X-ray diffraction
2.42Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PAN2-PAN3 deadenylation complex subunit PAN3 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 438 amino acids
Theoretical weight: 50.47 KDa
Source organism: Chaetomium thermophilum
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: G0S0Y3 (Residues: 205-640; Coverage: 68%)
Gene names: CTHT_0011660, PAN3
Sequence domains: Pan3 Pseudokinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ATP 8 x ATP
Ligand MG 8 x MG
1 modified residue:
Ligand MSE 72 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND
Spacegroup: P1
Unit cell:
a: 51.52Å b: 146.04Å c: 149.93Å
α: 89.81° β: 81.13° γ: 82.77°
R-values:
R R work R free
0.192 0.19 0.234
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

11 review citations

Towards a molecular understanding of microRNA-mediated gene silencing.
Jonas et al. (2015)
10 more

3 mentions without citation

Prospects for pharmacological targeting of pseudokinases.
Kung et al. (2019)
2 more