› 4csm

X-ray diffraction
2.8Å resolution

YEAST CHORISMATE MUTASE + TYR + ENDOOXABICYCLIC INHIBITOR

Released:
DOI: 10.2210/pdb4csm/pdb
PDB entry 4csm coloured by chain, front view.
PDB entry 4csm coloured by chain, side view.
PDB entry 4csm coloured by chain, top view.
Source organism: Saccharomyces cerevisiae
Primary publication:
Mechanisms of catalysis and allosteric regulation of yeast chorismate mutase from crystal structures.
Sträter N, Schnappauf G, Braus G, Lipscomb WN
Structure 5 1437-52 (1997)
PMID: 9384560

Function and Biology Details

Reaction catalysed: 
Chorismate = prephenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152224 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Chorismate mutase Chains: A, B
Molecule details ›
Chains: A, B
Length: 256 amino acids
Theoretical weight: 29.79 KDa
Source organism: Saccharomyces cerevisiae
Expression system: Saccharomyces cerevisiae
UniProt:
  • Canonical: P32178 (Residues: 1-256; Coverage: 100%)
Gene names: ARO7, OSM2, YP9499.15C, YPR060C
Structure domains: Chorismate mutase, AroQ class superfamily, eukaryotic

Ligands and Environments

2 bound ligands:
Ligand TYR 2 x TYR
Ligand TSA 2 x TSA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: R32
Unit cell:
a: 205.5Å b: 205.5Å c: 131.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.213 0.27
Expression system: Saccharomyces cerevisiae

Quick links

Citations

6 review citations

Epithelial tight junctions in intestinal inflammation.
Schulzke et al. (2009)
5 more

8 mentions without citation

Recognition of functional sites in protein structures.
Shulman-Peleg et al. (2004)
7 more