› 4caj

X-ray diffraction
2.19Å resolution

Crystallographic structure of the mouse SIGN-R1 CRD domain in complex with sialic acid

Released:
DOI: 10.2210/pdb4caj/pdb
PDB entry 4caj coloured by chain, front view.
PDB entry 4caj coloured by chain, side view.
PDB entry 4caj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural basis for selective recognition of endogenous and microbial polysaccharides by macrophage receptor SIGN-R1.
Silva-Martín N, Bartual SG, Ramírez-Aportela E, Chacón P, Park CG, Hermoso JA
Structure 22 1595-606 (2014)
PMID: 25450767

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-183990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
CD209 antigen-like protein B Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 158 amino acids
Theoretical weight: 17.97 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q8CJ91 (Residues: 191-325; Coverage: 42%)
Gene name: Cd209b
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

4 bound ligands:
Ligand CA 4 x CA
Ligand SO4 30 x SO4
Ligand SIA 3 x SIA
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: C2
Unit cell:
a: 146.2Å b: 94.47Å c: 76.14Å
α: 90° β: 121.42° γ: 90°
R-values:
R R work R free
0.209 0.205 0.281
Expression system: Cricetulus griseus

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Citations

6 review citations

Recent insights into structures and functions of C-type lectins in the immune system.
Drickamer et al. (2015)
5 more