› 4bhx

X-ray diffraction
1.95Å resolution

Crystal structure of the SCAN domain from human paternally expressed gene 3 protein

Released:
DOI: 10.2210/pdb4bhx/pdb
PDB entry 4bhx coloured by chain, front view.
PDB entry 4bhx coloured by chain, side view.
PDB entry 4bhx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the SCAN domain of human paternally expressed gene 3 protein.
Rimsa V, Eadsforth TC, Hunter WN
PLoS One 8 e69538 (2013)
PMID: 23936039

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190455 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Paternally-expressed gene 3 protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 11.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9GZU2 (Residues: 40-130; Coverage: 6%)
Gene names: KIAA0287, PEG3, ZSCAN24
Sequence domains: SCAN domain
Structure domains: DNA breaking-rejoining enzymes

Ligands and Environments

3 bound ligands:
Ligand PEG 4 x PEG
Ligand PGE 2 x PGE
Ligand EDO 21 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P65
Unit cell:
a: 83.615Å b: 83.615Å c: 55.233Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.174 0.172 0.224
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Role of the zinc finger and SCAN domain-containing transcription factors in cancer.
Huang et al. (2019)
7 other articles

3 mentions without citation

The Mutational Landscape of the Oncogenic MZF1 SCAN Domain in Cancer.
Nygaard et al. (2016)
2 more