› 4bd3

Solution NMR

Phf19 links methylated lysine 36 of histone H3 to regulation of Polycomb activity

Released:
DOI: 10.2210/pdb4bd3/pdb
PDB entry 4bd3 coloured by chain, ensemble of 10 models, front view.
PDB entry 4bd3 coloured by chain, ensemble of 10 models, side view.
PDB entry 4bd3 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.
Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L
Nat Struct Mol Biol 19 1257-65 (2012)
PMID: 23104054

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159414 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
PHD finger protein 19 Chain: A
Molecule details ›
Chain: A
Length: 58 amino acids
Theoretical weight: 6.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q5T6S3 (Residues: 38-95; Coverage: 10%)
Gene names: PCL3, PHF19
Sequence domains: Jumonji domain-containing protein 2A Tudor domain
Structure domains: SH3 type barrels.
Histone H3.1 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 32-42; Coverage: 8%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

No bound ligands
1 modified residue:
Ligand M3L 1 x M3L

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: ARIA
Expression systems:
  • Escherichia coli BL21
  • Not provided

Quick links

Citations

63 review citations

Transcriptional regulation by Polycomb group proteins.
Di Croce et al. (2013)
62 more

9 mentions without citation

Tudor: a versatile family of histone methylation 'readers'.
Lu et al. (2013)
8 more