› 4azp

X-ray diffraction
2.1Å resolution

Murine epidermal fatty acid-binding protein (FABP5) in complex with the endocannabinoid anandamide

Released:
DOI: 10.2210/pdb4azp/pdb
PDB entry 4azp coloured by chain, front view.
PDB entry 4azp coloured by chain, side view.
PDB entry 4azp coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.
Sanson B, Wang T, Sun J, Wang L, Kaczocha M, Ojima I, Deutsch D, Li H
Acta Crystallogr D Biol Crystallogr 70 290-8 (2014)
PMID: 24531463

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170252 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein 5 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.44 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q05816 (Residues: 1-135; Coverage: 100%)
Gene names: Fabp5, Fabpe, Klbp, Mal1
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

2 bound ligands:
Ligand A9M 1 x A9M
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P6422
Unit cell:
a: 79.71Å b: 79.71Å c: 83.15Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.199 0.236
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

From Phytocannabinoids to Cannabinoid Receptors and Endocannabinoids: Pleiotropic Physiological and Pathological Roles Through Complex Pharmacology.
Ligresti et al. (2016)
7 more

4 mentions without citation

Crystallographic study of FABP5 as an intracellular endocannabinoid transporter.
Sanson et al. (2014)
3 more