› 4apm

X-ray diffraction
2.3Å resolution

Crystal Structure of AMA1 from Babesia divergens

Released:
DOI: 10.2210/pdb4apm/pdb
PDB entry 4apm coloured by chain, front view.
PDB entry 4apm coloured by chain, side view.
PDB entry 4apm coloured by chain, top view.
Source organism: Babesia divergens
Primary publication:
Babesia divergens and Neospora caninum apical membrane antigen 1 structures reveal selectivity and plasticity in apicomplexan parasite host cell invasion.
Tonkin ML, Crawford J, Lebrun ML, Boulanger MJ
Protein Sci 22 114-27 (2013)
PMID: 23169033

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110983 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical membrane antigen 1 Chain: A
Molecule details ›
Chain: A
Length: 437 amino acids
Theoretical weight: 47.97 KDa
Source organism: Babesia divergens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: C0IR59 (Residues: 93-517; Coverage: 70%)
Sequence domains: Apical membrane antigen 1
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CA 1 x CA
Ligand ACT 3 x ACT
Ligand GOL 6 x GOL
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21212
Unit cell:
a: 67.82Å b: 139.18Å c: 45.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.25
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Vaccines against neosporosis: what can we learn from the past studies?
Monney et al. (2014)
1 more

4 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
3 more