› 4a14

X-ray diffraction
1.6Å resolution

HUMAN KIF7, A KINESIN INVOLVED IN HEDGEHOG SIGNALLING

Released:
DOI: 10.2210/pdb4a14/pdb
PDB entry 4a14 coloured by chain, front view.
PDB entry 4a14 coloured by chain, side view.
PDB entry 4a14 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human Kif7, a kinesin involved in Hedgehog signalling.
Klejnot M, Kozielski F
Acta Crystallogr D Biol Crystallogr 68 154-9 (2012)
PMID: 22281744

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF7 Chain: A
Molecule details ›
Chain: A
Length: 344 amino acids
Theoretical weight: 37.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q2M1P5 (Residues: 8-347; Coverage: 25%)
Gene names: KIF7, UNQ340/PRO539
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 45.991Å b: 79.799Å c: 95.094Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.182 0.207
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.
He et al. (2017)
2 more

19 mentions without citation

Multifaceted Pharmacological Potentials of Curcumin, Genistein, and Tanshinone IIA through Proteomic Approaches: An In-Depth Review.
Khan et al. (2022)
18 more