3zwx

X-ray diffraction
2.6Å resolution

Crystal structure of ADP-ribosyl cyclase complexed with 8-bromo-ADP- ribose

Released:
Source organism: Aplysia californica
Entry authors: Kotaka M, Graeff R, Zhang LH, Lee HC, Hao Q

Function and Biology Details

Reaction catalysed:
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide

Structure analysis Details

Assembly composition:
homo dimer (preferred)
PDBe Complex ID:
PDB-CPX-151371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 260 amino acids
Theoretical weight: 29.72 KDa
Source organism: Aplysia californica
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P29241 (Residues: 25-282; Coverage: 100%)
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Spacegroup: P1
Unit cell:
a: 60.682Å b: 76.818Å c: 140.333Å
α: 87.85° β: 89.25° γ: 89.12°
R-values:
R R work R free
0.206 0.203 0.271
Expression system: Komagataella pastoris