› 3wsx

X-ray diffraction
2.35Å resolution

SorLA Vps10p domain in ligand-free form

Released:
DOI: 10.2210/pdb3wsx/pdb
PDB entry 3wsx coloured by chain, front view.
PDB entry 3wsx coloured by chain, side view.
PDB entry 3wsx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for amyloidogenic peptide recognition by sorLA.
Kitago Y, Nagae M, Nakata Z, Yagi-Utsumi M, Takagi-Niidome S, Mihara E, Nogi T, Kato K, Takagi J
Nat Struct Mol Biol 22 199-206 (2015)
PMID: 25643321

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-187715 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sortilin-related receptor Chain: A
Molecule details ›
Chain: A
Length: 734 amino acids
Theoretical weight: 82.84 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q92673 (Residues: 29-753; Coverage: 33%)
Gene names: C11orf32, SORL1
Sequence domains:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

3 bound ligands:
Ligand NAG 3 x NAG
Ligand PO4 4 x PO4
Ligand EDO 6 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-17A
Spacegroup: P6122
Unit cell:
a: 126.371Å b: 126.371Å c: 290.282Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.208 0.238
Expression system: Cricetulus griseus

Quick links

Citations

12 review citations

Functional Roles of the Interaction of APP and Lipoprotein Receptors.
Pohlkamp et al. (2017)
11 more

3 mentions without citation

Structural insights into SorCS2-Nerve Growth Factor complex formation.
Leloup et al. (2018)
2 more