› 3wsj

X-ray diffraction
2.4Å resolution

HTLV-1 protease in complex with the HIV-1 protease inhibitor Indinavir

Released:
DOI: 10.2210/pdb3wsj/pdb
PDB entry 3wsj coloured by chain, front view.
PDB entry 3wsj coloured by chain, side view.
PDB entry 3wsj coloured by chain, top view.
Source organism: Human T-cell leukemia virus type I
Primary publication:
Structural basis for HTLV-1 protease inhibition by the HIV-1 protease inhibitor indinavir.
Kuhnert M, Steuber H, Diederich WE
J Med Chem 57 6266-72 (2014)
PMID: 25006983

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-182639 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.57 KDa
Source organism: Human T-cell leukemia virus type I
Expression system: Escherichia coli
UniProt:
  • Canonical: Q82134 (Residues: 1-116; Coverage: 93%)
Gene name: prt
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

3 bound ligands:
Ligand MK1 1 x MK1
Ligand SO4 13 x SO4
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P6322
Unit cell:
a: 77.26Å b: 77.26Å c: 159.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.209 0.205 0.256
Expression system: Escherichia coli

Quick links

Citations

6 citation in other articles

Portrait of the Intrinsically Disordered Side of the HTLV-1 Proteome.
Lyngdoh et al. (2019)
5 more

5 mentions without citation

Updates to Binding MOAD (Mother of All Databases): Polypharmacology Tools and Their Utility in Drug Repurposing.
Smith et al. (2019)
4 more