› 3wrd

X-ray diffraction
2.86Å resolution

Crystal Structure of the KIF5C Motor Domain Without Any Nucleotide

Released:
DOI: 10.2210/pdb3wrd/pdb
PDB entry 3wrd coloured by chain, front view.
PDB entry 3wrd coloured by chain, side view.
PDB entry 3wrd coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding.
Morikawa M, Yajima H, Nitta R, Inoue S, Ogura T, Sato C, Hirokawa N
EMBO J 34 1270-86 (2015)
PMID: 25777528

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151276 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin heavy chain isoform 5C Chains: A, B
Molecule details ›
Chains: A, B
Length: 341 amino acids
Theoretical weight: 38.26 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P28738 (Residues: 1-334; Coverage: 35%)
Gene names: Kif5c, Nkhc2
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P212121
Unit cell:
a: 71.585Å b: 71.322Å c: 176.163Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.24 0.237 0.299
Expression system: Escherichia coli

Quick links

Citations

12 review citations

The axonal cytoskeleton: from organization to function.
Kevenaar et al. (2015)
11 more

3 mentions without citation

X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding.
Morikawa et al. (2015)
2 more