Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- RNA polymerase sigma-70
- DNA-directed RNA polymerase, insert domain superfamily
- DNA-directed RNA polymerase, RpoA/D/Rpb3-type
- RNA polymerase, RBP11-like subunit
- DNA-directed RNA polymerase, alpha subunit
- Winged helix-like DNA-binding domain superfamily
- RNA polymerase sigma factor, region 3/4-like
- RNA polymerase, subunit omega/Rpo6/RPB6
36 more domains
Structure analysis Details
Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-108487 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
DNA-directed RNA polymerase subunit alpha
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.06 KDa
Source organism: Thermus thermophilus HB8
UniProt:
Sequence domains:
Length: 315 amino acids
Theoretical weight: 35.06 KDa
Source organism: Thermus thermophilus HB8
UniProt:
- Canonical:
Q5SHR6 (Residues: 1-315; Coverage: 100%)
Sequence domains:
- RNA polymerase Rpb3/Rpb11 dimerisation domain
- RNA polymerase Rpb3/RpoA insert domain
- Bacterial RNA polymerase, alpha chain C terminal domain
DNA-directed RNA polymerase subunit beta
Molecule details ›
Chain: C
Length: 1119 amino acids
Theoretical weight: 125.44 KDa
Source organism: Thermus thermophilus HB8
UniProt:
Sequence domains:
Length: 1119 amino acids
Theoretical weight: 125.44 KDa
Source organism: Thermus thermophilus HB8
UniProt:
- Canonical: Q8RQE9 (Residues: 1-1119; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit beta'
Molecule details ›
Chain: D
Length: 1524 amino acids
Theoretical weight: 171 KDa
Source organism: Thermus thermophilus HB8
UniProt:
Sequence domains:
Length: 1524 amino acids
Theoretical weight: 171 KDa
Source organism: Thermus thermophilus HB8
UniProt:
- Canonical: Q8RQE8 (Residues: 1-1524; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit omega
Molecule details ›
Chain: E
Length: 99 amino acids
Theoretical weight: 11.52 KDa
Source organism: Thermus thermophilus HB8
UniProt:
Sequence domains: RNA polymerase Rpb6
Structure domains: Eukaryotic RPB6 RNA polymerase subunit
Length: 99 amino acids
Theoretical weight: 11.52 KDa
Source organism: Thermus thermophilus HB8
UniProt:
- Canonical: Q8RQE7 (Residues: 1-99; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
Structure domains: Eukaryotic RPB6 RNA polymerase subunit
RNA polymerase sigma factor SigA
Molecule details ›
Chain: F
Length: 423 amino acids
Theoretical weight: 48.6 KDa
Source organism: Thermus thermophilus HB8
UniProt:
Sequence domains:
Structure domains:
Length: 423 amino acids
Theoretical weight: 48.6 KDa
Source organism: Thermus thermophilus HB8
UniProt:
- Canonical: Q5SKW1 (Residues: 1-423; Coverage: 100%)
Sequence domains:
Structure domains:
Putative uncharacterized protein
Molecule details ›
Chains: G, H
Length: 141 amino acids
Theoretical weight: 16.23 KDa
Source organism: Oshimavirus P2345
Expression system: Escherichia coli
UniProt:
Sequence domains: Thermus phage P23-45 gp39, N-terminal domain
Structure domains: SH3 type barrels.
Length: 141 amino acids
Theoretical weight: 16.23 KDa
Source organism: Oshimavirus P2345
Expression system: Escherichia coli
UniProt:
- Canonical: A7XX65 (Residues: 1-141; Coverage: 100%)
Sequence domains: Thermus phage P23-45 gp39, N-terminal domain
Structure domains: SH3 type barrels.
