› 3w1w

X-ray diffraction
2.01Å resolution

Protein-drug complex

Released:
DOI: 10.2210/pdb3w1w/pdb
PDB entry 3w1w coloured by chain, front view.
PDB entry 3w1w coloured by chain, side view.
PDB entry 3w1w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Salicylic acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity.
Gupta V, Liu S, Ando H, Ishii R, Tateno S, Kaneko Y, Yugami M, Sakamoto S, Yamaguchi Y, Nureki O, Handa H
Mol Pharmacol 84 824-33 (2013)
PMID: 24043703

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149809 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferrochelatase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 371 amino acids
Theoretical weight: 42.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22830 (Residues: 61-423; Coverage: 86%)
Gene name: FECH
Sequence domains: Ferrochelatase
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand FES 2 x FES
Ligand CHD 8 x CHD
Ligand SAL 1 x SAL
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P212121
Unit cell:
a: 87.531Å b: 93.627Å c: 110.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.191 0.229
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Protoporphyrin IX: the Good, the Bad, and the Ugly.
Sachar et al. (2016)
6 more

2 mentions without citation

Small-molecule inhibitors of ferrochelatase are antiangiogenic agents.
Sishtla et al. (2022)
1 more