› 3uzp

X-ray diffraction
1.94Å resolution

crystal structure of ck1d with PF670462 from P21 crystal form

Released:
DOI: 10.2210/pdb3uzp/pdb
PDB entry 3uzp coloured by chain, front view.
PDB entry 3uzp coloured by chain, side view.
PDB entry 3uzp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the interaction between casein kinase 1 delta and a potent and selective inhibitor.
Long A, Zhao H, Huang X
J Med Chem 55 956-60 (2012)
PMID: 22168824

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [tau protein] = ADP + [tau protein] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-155796 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Casein kinase I isoform delta Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 34.35 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P48730 (Residues: 1-294; Coverage: 71%)
Gene names: CSNK1D, HCKID
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 0CK 2 x 0CK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P21
Unit cell:
a: 49Å b: 72.8Å c: 88.99Å
α: 90° β: 103.21° γ: 90°
R-values:
R R work R free
0.222 0.222 0.237
Expression system: Spodoptera frugiperda

Quick links

Citations

5 review citations

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D).
Xu et al. (2019)
4 more

14 mentions without citation

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis.
Knippschild et al. (2014)
13 more