› 3ux3

X-ray diffraction
1.8Å resolution

Crystal Structure of Domain-Swapped Fam96a minor dimer

Released:
DOI: 10.2210/pdb3ux3/pdb
PDB entry 3ux3 coloured by chain, front view.
PDB entry 3ux3 coloured by chain, side view.
PDB entry 3ux3 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The mammalian DUF59 protein Fam96a forms two distinct types of domain-swapped dimer.
Chen KE, Richards AA, Ariffin JK, Ross IL, Sweet MJ, Kellie S, Kobe B, Martin JL
Acta Crystallogr D Biol Crystallogr 68 637-48 (2012)
PMID: 22683786

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190629 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic iron-sulfur assembly component 2A Chains: A, B
Molecule details ›
Chains: A, B
Length: 130 amino acids
Theoretical weight: 15.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H5X1 (Residues: 31-157; Coverage: 79%)
Gene names: CIA2A, CIAO2A, FAM96A
Sequence domains: Iron-sulfur cluster assembly protein
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ZN 3 x ZN
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P21
Unit cell:
a: 49.179Å b: 52.246Å c: 65.893Å
α: 90° β: 104.56° γ: 90°
R-values:
R R work R free
0.203 0.2 0.246
Expression system: Escherichia coli

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Citations

5 review citations

Emerging critical roles of Fe-S clusters in DNA replication and repair.
Fuss et al. (2015)
4 more