› 3uj1

X-ray diffraction
2.65Å resolution

Crystal structure of the third thioredoxin domain of human ERp46

Released:
DOI: 10.2210/pdb3uj1/pdb
PDB entry 3uj1 coloured by chain, front view.
PDB entry 3uj1 coloured by chain, side view.
PDB entry 3uj1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Peptide binding by catalytic domains of the protein disulfide isomerase-related protein ERp46.
Funkner A, Parthier C, Schutkowski M, Zerweck J, Lilie H, Gyrych N, Fischer G, Stubbs MT, Ferrari DM
J Mol Biol 425 1340-62 (2013)
PMID: 23376096

Function and Biology Details

Reaction catalysed: 
Catalyzes the rearrangement of -S-S- bonds in proteins
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185480 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thioredoxin domain-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 110 amino acids
Theoretical weight: 12.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8NBS9 (Residues: 323-432; Coverage: 28%)
Gene names: TLP46, TXNDC5, UNQ364/PRO700
Sequence domains: Thioredoxin
Structure domains: Glutaredoxin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P3221
Unit cell:
a: 63.58Å b: 63.58Å c: 68.68Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.229 0.259
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Calnexin cycle - structural features of the ER chaperone system.
Kozlov et al. (2020)
4 more

1 mention without citation

Functions and mechanisms of protein disulfide isomerase family in cancer emergence.
Rahman et al. (2022)