› 3u21

X-ray diffraction
2.18Å resolution

Crystal structure of a Fragment of Nuclear factor related to kappa-B-binding protein (residues 370-495) (NFRKB) from Homo sapiens at 2.18 A resolution

Released:
DOI: 10.2210/pdb3u21/pdb
PDB entry 3u21 coloured by chain, front view.
PDB entry 3u21 coloured by chain, side view.
PDB entry 3u21 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of a novel winged-helix like domain from human NFRKB protein.
Kumar A, Möcklinghoff S, Yumoto F, Jaroszewski L, Farr CL, Grzechnik A, Nguyen P, Weichenberger CX, Chiu HJ, Klock HE, Elsliger MA, Deacon AM, Godzik A, Lesley SA, Conklin BR, Fletterick RJ, Wilson IA
PLoS One 7 e43761 (2012)
PMID: 22984442

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180116 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nuclear factor related to kappa-B-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6P4R8 (Residues: 370-495; Coverage: 10%)
Gene names: INO80G, NFRKB
Sequence domains: NFRKB Winged Helix-like
Structure domains: NFRKB winged helix-like domain

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
2 modified residues:
Ligand MSE 2 x MSE
Ligand MLY 12 x MLY

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P43212
Unit cell:
a: 60.942Å b: 60.942Å c: 130.839Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.27
Expression system: Escherichia coli

Quick links

Citations

4 citation in other articles

Structural basis for microtubule recognition by the human kinetochore Ska complex.
Abad et al. (2014)
3 more

5 mentions without citation

The role of the interactome in the maintenance of deleterious variability in human populations.
Garcia-Alonso et al. (2014)
4 more