› 3suz

X-ray diffraction
2.7Å resolution

Crystal structure of Rat Mint2 PPC

Released:
DOI: 10.2210/pdb3suz/pdb
PDB entry 3suz coloured by chain, front view.
PDB entry 3suz coloured by chain, side view.
PDB entry 3suz coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Open-closed motion of Mint2 regulates APP metabolism.
Xie X, Yan X, Wang Z, Zhou H, Diao W, Zhou W, Long J, Shen Y
J Mol Cell Biol 5 48-56 (2013)
PMID: 22730553

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128681 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Amyloid-beta A4 precursor protein-binding family A member 2 Chain: A
Molecule details ›
Chain: A
Length: 388 amino acids
Theoretical weight: 42.55 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O35431 (Residues: 365-750; Coverage: 52%)
Gene names: Apba2, Mint2
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3221
Unit cell:
a: 111.662Å b: 111.662Å c: 84.586Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.265 0.265 0.289
Expression system: Escherichia coli

Quick links

Citations

2 review citations

PDZ Domains as Drug Targets.
Christensen et al. (2019)
1 more

2 mentions without citation

A rare autism-associated MINT2/APBA2 mutation disrupts neurexin trafficking and synaptic function.
Lin et al. (2019)
1 more