› 3sp8

X-ray diffraction
1.86Å resolution

Crystal structure of NK2 in complex with fractionated Heparin DP10

Released:
DOI: 10.2210/pdb3sp8/pdb
PDB entry 3sp8 coloured by chain, front view.
PDB entry 3sp8 coloured by chain, side view.
PDB entry 3sp8 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Recacha R, Mulloy B, Gherardi E

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146876 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatocyte growth factor alpha chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 30.91 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P14210 (Residues: 28-288; Coverage: 37%)
Gene names: HGF, HPTA
Sequence domains:
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand MRD 4 x MRD
Ligand MES 4 x MES
Ligand MPD 1 x MPD
Ligand SO4 10 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P61
Unit cell:
a: 75.98Å b: 75.98Å c: 199.62Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.188 0.187 0.217
Expression system: Komagataella pastoris

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