› 3sfz

X-ray diffraction
3Å resolution

Crystal structure of full-length murine Apaf-1

Released:
DOI: 10.2210/pdb3sfz/pdb
PDB entry 3sfz coloured by chain, front view.
PDB entry 3sfz coloured by chain, side view.
PDB entry 3sfz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.
Reubold TF, Wohlgemuth S, Eschenburg S
Structure 19 1074-83 (2011)
PMID: 21827944

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131594 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

2 bound ligands:
Ligand ADP 1 x ADP
Ligand GBL 5 x GBL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 72.65Å b: 113.07Å c: 243.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.236 0.236 0.298
Expression system: Antheraea

Quick links

Citations

20 review citations

Regulation of the intrinsic apoptosis pathway by reactive oxygen species.
Wu et al. (2013)
19 more

12 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
11 more