› 3sd4

X-ray diffraction
1.93Å resolution

Crystal structure of the first Tudor domain of human PHF20

Released:
DOI: 10.2210/pdb3sd4/pdb
PDB entry 3sd4 coloured by chain, front view.
PDB entry 3sd4 coloured by chain, side view.
PDB entry 3sd4 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G
Nat Struct Mol Biol 19 916-24 (2012)
PMID: 22864287

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189760 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PHD finger protein 20 Chains: A, B
Molecule details ›
Chains: A, B
Length: 69 amino acids
Theoretical weight: 8.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9BVI0 (Residues: 4-69; Coverage: 7%)
Gene names: C20orf104, GLEA2, HCA58, NZF, PHF20, TZP
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 37.746Å b: 60.761Å c: 37.75Å
α: 90° β: 112.82° γ: 90°
R-values:
R R work R free
0.23 0.229 0.236
Expression system: Escherichia coli BL21

Quick links

Citations

20 review citations

Non-histone protein methylation as a regulator of cellular signalling and function.
Biggar et al. (2015)
19 more

2 mentions without citation

Catching Nucleosome by Its Decorated Tails Determines Its Functional States.
Sehrawat et al. (2022)
1 more