› 3r7x

X-ray diffraction
2.1Å resolution

Crystal Structure Analysis of a Quinazolinedione sulfonamide bound to human GluR2: A Novel Class of Competitive AMPA Receptor Antagonists with Oral Activity

Released:
DOI: 10.2210/pdb3r7x/pdb
PDB entry 3r7x coloured by chain, front view.
PDB entry 3r7x coloured by chain, side view.
PDB entry 3r7x coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity.
Koller M, Lingenhoehl K, Schmutz M, Vranesic IT, Kallen J, Auberson YP, Carcache DA, Mattes H, Ofner S, Orain D, Urwyler S
Bioorg Med Chem Lett 21 3358-61 (2011)
PMID: 21531559

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154589 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 263 amino acids
Theoretical weight: 29.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P42262 (Residues: 413-527, 653-796; Coverage: 30%)
Gene names: GLUR2, GRIA2, GluA2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand QSN 1 x QSN
Ligand GLU 1 x GLU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 57.36Å b: 88.578Å c: 97.626Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.204 0.25
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Comprehensive review in current developments of imidazole-based medicinal chemistry.
Zhang et al. (2014)
7 more

3 mentions without citation

Size matters in activation/inhibition of ligand-gated ion channels.
Du et al. (2012)
2 more