› 3qym

X-ray diffraction
3.2Å resolution

Structure of p63 DNA Binding Domain in Complex with a 10 Base Pair A/T Rich Response Element Half Site

Released:
DOI: 10.2210/pdb3qym/pdb
PDB entry 3qym coloured by chain, front view.
PDB entry 3qym coloured by chain, side view.
PDB entry 3qym coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of p63 DNA binding domain in complexes with half-site and with spacer-containing full response elements.
Chen C, Gorlatova N, Kelman Z, Herzberg O
Proc Natl Acad Sci U S A 108 6456-61 (2011)
PMID: 21464285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-116789 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Tumor protein 63 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 203 amino acids
Theoretical weight: 22.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H3D4 (Residues: 166-362; Coverage: 29%)
Gene names: KET, P63, P73H, P73L, TP63, TP73L
Sequence domains: P53 DNA-binding domain
Structure domains: Immunoglobulin-like
5'-D(*AP*AP*AP*CP*AP*TP*GP*TP*TP*T)-3' Chains: I, J, K, L, M, N, O, P
Molecule details ›
Chains: I, J, K, L, M, N, O, P
Length: 10 nucleotides
Theoretical weight: 3.04 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand ZN 8 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: C2
Unit cell:
a: 123.872Å b: 180.198Å c: 104.379Å
α: 90° β: 92.62° γ: 90°
R-values:
R R work R free
0.246 0.245 0.271
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

7 review citations

p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis.
Su et al. (2013)
6 more

9 mentions without citation

Structural diversity of p63 and p73 isoforms.
Osterburg et al. (2022)
8 more