› 3q2e

X-ray diffraction
1.74Å resolution

Crystal structure of the second bromodomain of human bromodomain and WD repeat-containing protein 1 isoform A (WDR9)

Released:
DOI: 10.2210/pdb3q2e/pdb
PDB entry 3q2e coloured by chain, front view.
PDB entry 3q2e coloured by chain, side view.
PDB entry 3q2e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Histone recognition and large-scale structural analysis of the human bromodomain family.
Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Müller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S
Cell 149 214-31 (2012)
PMID: 22464331

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192592 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain and WD repeat-containing protein 1 Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 14.45 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NSI6 (Residues: 1310-1430; Coverage: 5%)
Gene names: BRWD1, C21orf107, WDR9
Sequence domains: Bromodomain
Structure domains: Bromodomain-like

Ligands and Environments

1 bound ligand:
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P6122
Unit cell:
a: 51.66Å b: 51.66Å c: 151.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.185 0.219
Expression system: Escherichia coli

Quick links

Citations

245 review citations

Modification of enhancer chromatin: what, how, and why?
Calo et al. (2013)
244 more

2 mentions without citation

Large-scale analysis of water stability in bromodomain binding pockets with grand canonical Monte Carlo.
Aldeghi et al. (2018)
1 more