› 3pzf

X-ray diffraction
1.75Å resolution

1.75A resolution structure of Serpin-2 from Anopheles gambiae

Released:
DOI: 10.2210/pdb3pzf/pdb
PDB entry 3pzf coloured by chain, front view.
PDB entry 3pzf coloured by chain, side view.
PDB entry 3pzf coloured by chain, top view.
Source organism: Anopheles gambiae
Primary publication:
Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes.
An C, Lovell S, Kanost MR, Battaile KP, Michel K
Proteins 79 1999-2003 (2011)
PMID: 21465556

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181881 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor 2 Chain: A
Molecule details ›
Chain: A
Length: 397 amino acids
Theoretical weight: 45.36 KDa
Source organism: Anopheles gambiae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q7QIJ8 (Residues: 22-409; Coverage: 100%)
Gene names: 1270169, AgaP_AGAP006911, SRPN2
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P63
Unit cell:
a: 96.538Å b: 96.538Å c: 78.289Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.173 0.207
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

The roles of serpins in mosquito immunology and physiology.
Gulley et al. (2013)
5 other articles

7 mentions without citation

Serpins in arthropod biology.
Meekins et al. (2017)
6 more