› 3pls

X-ray diffraction
2.24Å resolution

RON in complex with ligand AMP-PNP

Released:
DOI: 10.2210/pdb3pls/pdb
PDB entry 3pls coloured by chain, front view.
PDB entry 3pls coloured by chain, side view.
PDB entry 3pls coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of a constitutively active mutant RON kinase suggests an intramolecular autophosphorylation hypothesis.
Wang J, Steinbacher S, Augustin M, Schreiner P, Epstein D, Mulvihill MJ, Crew AP
Biochemistry 49 7972-4 (2010)
PMID: 20726546

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170090 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Macrophage-stimulating protein receptor beta chain Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 34.25 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q04912 (Residues: 1060-1357; Coverage: 22%)
Gene names: MST1R, PTK8, RON
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand ANP 1 x ANP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: P41
Unit cell:
a: 98.631Å b: 98.631Å c: 45.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.231 0.29
Expression system: Spodoptera frugiperda

Quick links

Citations

4 review citations

MSP-RON signalling in cancer: pathogenesis and therapeutic potential.
Yao et al. (2013)
3 more

9 mentions without citation

Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family.
Artim et al. (2012)
8 more