› 3o51

X-ray diffraction
3.2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127232 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Aurora kinase A Chain: A
Molecule details ›
Chain: A
Length: 267 amino acids
Theoretical weight: 31.04 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O14965 (Residues: 125-391; Coverage: 66%)
Gene names: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LJF 1 x LJF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P41212
Unit cell:
a: 86.658Å b: 86.658Å c: 76.753Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.288 0.288 0.304
Expression system: Spodoptera frugiperda

Quick links

Citations

6 citation in other articles

Development of o-chlorophenyl substituted pyrimidines as exceptionally potent aurora kinase inhibitors.
Lawrence et al. (2012)
5 more

2 mentions without citation

Kinase Atlas: Druggability Analysis of Potential Allosteric Sites in Kinases.
Yueh et al. (2019)
1 more