› 3m2m

X-ray diffraction
2.95Å resolution

Rat galectin-1 complex with lactose

Released:
DOI: 10.2210/pdb3m2m/pdb
PDB entry 3m2m coloured by chain, front view.
PDB entry 3m2m coloured by chain, side view.
PDB entry 3m2m coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Monovalent interactions of galectin-1.
Salomonsson E, Larumbe A, Tejler J, Tullberg E, Rydberg H, Sundin A, Khabut A, Frejd T, Lobsanov YD, Rini JM, Nilsson UJ, Leffler H
Biochemistry 49 9518-32 (2010)
PMID: 20873803

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-145916 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-1 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 134 amino acids
Theoretical weight: 14.77 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P11762 (Residues: 2-135; Coverage: 99%)
Gene name: Lgals1
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
No bound ligands
1 modified residue:
Ligand CSO 16 x CSO

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH2R
Spacegroup: P1
Unit cell:
a: 40.1Å b: 58.6Å c: 121.6Å
α: 101.1° β: 91.6° γ: 110.9°
R-values:
R R work R free
0.233 0.206 0.248
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Galectins at a glance.
Johannes et al. (2018)
4 more

1 mention without citation

Glycomimetics for the inhibition and modulation of lectins.
Leusmann et al. (2023)