› 3lw2

X-ray diffraction
1.93Å resolution

Mouse Plasminogen Activator Inhibitor-1 (PAI-1)

Released:
DOI: 10.2210/pdb3lw2/pdb
PDB entry 3lw2 coloured by chain, front view.
PDB entry 3lw2 coloured by chain, side view.
PDB entry 3lw2 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
Dewilde M, Van De Craen B, Compernolle G, Madsen JB, Strelkov S, Gils A, Declerck PJ
J Struct Biol 171 95-101 (2010)
PMID: 20230900

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149799 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plasminogen activator inhibitor 1 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 42.8 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P22777 (Residues: 24-402; Coverage: 100%)
Gene names: Mr1, Pai1, Planh1, Serpine1
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 150.9Å b: 62.3Å c: 52.2Å
α: 90° β: 105.5° γ: 90°
R-values:
R R work R free
0.183 0.181 0.218
Expression system: Escherichia coli

Quick links

Citations

1 review citation

From Bedside to the Bench-A Call for Novel Approaches to Prognostic Evaluation and Treatment of Empyema.
Karandashova et al. (2021)
12 other articles

2 mentions without citation

A protein chimera strategy supports production of a model "difficult-to-express" recombinant target.
Hussain et al. (2018)
1 more