› 3lsw

X-ray diffraction
1.75Å resolution

Aniracetam bound to the ligand binding domain of GluA3

Released:
DOI: 10.2210/pdb3lsw/pdb
PDB entry 3lsw coloured by chain, front view.
PDB entry 3lsw coloured by chain, side view.
PDB entry 3lsw coloured by chain, top view.
Source organisms:
Primary publication:
Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.
Ahmed AH, Oswald RE
J Med Chem 53 2197-203 (2010)
PMID: 20163115

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148614 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 3 Chain: A
Molecule details ›
Chain: A
Length: 258 amino acids
Theoretical weight: 28.96 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: P19492 (Residues: 417-530, 658-769; Coverage: 26%)
  • Canonical: Q9Z2W9 (Residues: 770-799; Coverage: 4%)
Gene names: GluA3, Glur3, Gria3, Kiaa4184
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand GLU 1 x GLU
Ligand 4MP 1 x 4MP
Ligand ZN 2 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P2221
Unit cell:
a: 47.06Å b: 47.364Å c: 137.409Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.179 0.217
Expression system: Escherichia coli

Quick links

Citations

15 review citations

Functional insights from glutamate receptor ion channel structures.
Kumar et al. (2013)
14 more

2 mentions without citation

Diversity of AMPA Receptor Ligands: Chemotypes, Binding Modes, Mechanisms of Action, and Therapeutic Effects.
Golubeva et al. (2022)
1 more