› 3lbj

X-ray diffraction
1.5Å resolution

Structure of human MDMX protein in complex with a small molecule inhibitor

Released:
DOI: 10.2210/pdb3lbj/pdb
PDB entry 3lbj coloured by chain, front view.
PDB entry 3lbj coloured by chain, side view.
PDB entry 3lbj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.
Popowicz GM, Czarna A, Wolf S, Wang K, Wang W, Dömling A, Holak TA
Cell Cycle 9 1104-11 (2010)
PMID: 20237429

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chain: E
Molecule details ›
Chain: E
Length: 90 amino acids
Theoretical weight: 10.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain

Ligands and Environments

2 bound ligands:
Ligand WW8 2 x WW8
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: I213
Unit cell:
a: 80.97Å b: 80.97Å c: 80.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.176 0.174 0.206
Expression system: Escherichia coli

Quick links

Citations

31 review citations

MDM2, MDMX and p53 in oncogenesis and cancer therapy.
Wade et al. (2013)
30 more

23 mentions without citation

Chemistry and biology of multicomponent reactions.
Dömling et al. (2012)
22 more