› 3l0e

X-ray diffraction
2.3Å resolution

X-ray crystal structure of a Potent Liver X Receptor Modulator

Released:
DOI: 10.2210/pdb3l0e/pdb
PDB entry 3l0e coloured by chain, front view.
PDB entry 3l0e coloured by chain, side view.
PDB entry 3l0e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery of tertiary sulfonamides as potent liver X receptor antagonists.
Zuercher WJ, Buckholz RG, Campobasso N, Collins JL, Galardi CM, Gampe RT, Hyatt SM, Merrihew SL, Moore JT, Oplinger JA, Reid PR, Spearing PK, Stanley TB, Stewart EL, Willson TM
J Med Chem 53 3412-6 (2010)
PMID: 20345102

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-157160 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Oxysterols receptor LXR-beta Chain: A
Molecule details ›
Chain: A
Length: 253 amino acids
Theoretical weight: 28.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55055 (Residues: 212-460; Coverage: 54%)
Gene names: LXRB, NER, NR1H2, UNR
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 12 amino acids
Theoretical weight: 1.48 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 740-751; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand G58 1 x G58
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P4122
Unit cell:
a: 114.855Å b: 114.855Å c: 56.407Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.203 0.202 0.237
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

7 review citations

Targeting liver X receptors in inflammation.
Steffensen et al. (2013)
6 more

3 mentions without citation

Ligands of Therapeutic Utility for the Liver X Receptors.
Komati et al. (2017)
2 more